SILDENAFIL STRUCTURE - AN OVERVIEW

Contraindicated (one)cobicistat will raise the amount or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.Consider decreasing the dose from the sensitive CYP3A4 substrate and watch for signs of toxicities of the coadministered delicate CYP3A substrate.Watch blood pressure reaction to sildenafil in patients obtaining con